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Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice

Posted on 2019-10-11 - 13:16
We report the use of an electrically tunable lens (ETL) in a 1.3-μm spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral blood flow imaging of all cortical layers by stitching the OCTA images automatically captured at 6 focal depths. Capillary vasculature and axial blood flow velocity were revealed in distinctive cortical layers, and for the first time, in white matter. The implementation of ETL will enable many future OCTA applications in deep cortical layers to benefit a comprehensive investigation of the neurovascular function in brain activities and pathologies.

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AUTHORS (5)

Yuandong Li
Peijun Tang
Shaozhen Song
Adiya Rakymzhan
Ruikang Wang

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