Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Version 2 2020-07-28, 17:21
Version 1 2020-07-28, 17:21
Posted on 2020-07-28 - 17:21
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region
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Mittal, Vinita; Devitt, George; Nedeljkovic, Milos; Carpenter, Lewis; Chong, Harold; Wilkinson, James; et al. (2020). Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.5068697.v2
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AUTHORS (8)
VM
Vinita Mittal
GD
George Devitt
MN
Milos Nedeljkovic
LC
Lewis Carpenter
HC
Harold Chong
JW
James Wilkinson
SM
Sumeet Mahajan
GM
Goran Mashanovich