Interstitial magnetic thermotherapy dosimetry
based on shear wave magnetomotive optical
coherence elastography
Posted on 2019-01-14 - 21:09
While magnetic thermoseeds are often utilized in interstitial magnetic
thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the
perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the
heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements
were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated
porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal
damages. Additionally, the elasticity was found to increase exponentially and linearly with
the conventional thermal dosage metrics and the deposited thermal energy, respectively.
Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.
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Huang, Pin; Chaney, Eric; Iyer, Rishyashring; Spillman, Darold; Odintsov, Boris; Sobh, Nahil; et al. (2019). Interstitial magnetic thermotherapy dosimetry
based on shear wave magnetomotive optical
coherence elastography. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4288259.v1
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AUTHORS (7)
PH
Pin Huang
EC
Eric Chaney
RI
Rishyashring Iyer
DS
Darold Spillman
BO
Boris Odintsov
NS
Nahil Sobh
SB
Stephen Boppart