Simultaneous in-vivo FF-OCT/SD-OCT retinal imaging with optical stabilization of axial motion

Time-domain Full-Field OCT (FF-OCT) represents an imaging modality capable of recording high-speed en-face sections of a sample at a given depth. One of the biggest challenges to transfer this technique to image in-vivo human retina is the presence of continuous involuntary head and eye axial motion during image acquisition. In this paper, we present a multimodal retinal imaging system combining time-domain FF-OCT, spectral-domain OCT (SD-OCT) and the capacity to optically correct for axial motion. B-scans generated by the SD-OCT are used to measure the retina axial position and to drive the position of a high-speed voice coil translation stage, where the FF-OCT reference arm is mounted. By these means, we demonstrate the ability of our multimodal imaging system to simultaneously record and display in real-time both en-face and cross-section views of the living human retina. We show that both views present sufficient consistency and resolution to identify all retinal layers, from the SD-OCT generated cross-sections, and to resolve cone mosaic as close as 1.5o from the fovea center, from FF-OCT generated en-face images, without using adaptive optics.