Single-cell terahertz spectral characteristics
in simulated scattering near-field imaging
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Posted on 2020-08-05 - 15:43
Spectral imaging of a single cell with terahertz (THz) wave is valuable in
determination of its physiological state for cell-based precision diagnosis, as THz photon
energy is in tune with the vibration-rotation and conformation related excitations of cellular
material, and THz absorption is extremely sensitive to the state and degree of hydration of a
cell. Because of the severe mismatch between the cell size and the THz wavelength, such
imaging has to be carried out in the near-field modality. To make the design and performance
assessment of a THz near-field spectral imager effective and systematic, we simulate the
scattering THz near-field signals of tumor cells by strictly controlling cell model parameters
with representative physiological states. The results demonstrate that the specific
physiological characteristics from intracellular hydration state, nucleocytoplasmic ratio, and
cell geometric morphology of tumor cells can be characterized quantitatively by their
discrepant dielectric response in the THz band, correlating THz near-field scattering signal
from a cell with the latter’s corresponding physicochemical state.
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Wang, Jie; Yan, Shihan; Li, Zaoxia; Zang, Ziyi; Lu, Xingxing; Cui, Hongliang (2020). Single-cell terahertz spectral characteristics
in simulated scattering near-field imaging
mode. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.5066006.v8
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AUTHORS (6)
JW
Jie Wang
SY
Shihan Yan
ZL
Zaoxia Li
ZZ
Ziyi Zang
XL
Xingxing Lu
HC
Hongliang Cui