Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging
Posted on 2020-05-26 - 18:31
Laser Doppler holography (LDH) is a full-field interferometric imaging technique
recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest.
From the temporal fluctuations of digital holograms acquired at ultrafast frame rates, LDH
reveals retinal and choroidal blood flow with a few milliseconds of temporal resolution. However
LDH experiences difficulties to detect slower blood flow as it requires to work with low Doppler
frequency shifts which are corrupted by eye motion. We here demonstrate the use of a spatiotemporal decomposition adapted from Doppler ultrasound that provides a basis appropriate to
the discrimination of blood flow from eye motion. A singular value decomposition (SVD) can be
used as a simple, robust, and efficient way to separate the Doppler fluctuations of blood flow
from those of strong spatial coherence such as eye motion. We show that the SVD outperforms
the conventional Fourier based filter to reveal slower blood flow, and dramatically improves the
ability of LDH to reveal vessels of smaller size or with a pathologically reduced blood flow.
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Puyo, Léo; Paques, Michel; Atlan, Michael (2020). Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4893828.v1
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AUTHORS (3)
LP
Léo Puyo
MP
Michel Paques
MA
Michael Atlan