Speckle-free, near-infrared portable confocal
microscope
Posted on 2020-05-26 - 16:01
We have developed a portable confocal microscope (PCM) that uses an
inexpensive near-infrared (NIR) LED as the light source. Use of the spatially incoherent light
source significantly reduced the speckle contrast. The PCM device was manufactured at the
material cost of approximately $5,000 and weighed only 1 kg. Lateral and axial resolutions
were measured as 1.6 µm and 6.0 µm, respectively. Preliminary in vivo skin imaging
experiment results showed that the PCM device could visualize characteristic cellular features
of human skin extending from the stratum corneum to the superficial dermis. Dynamic
imaging of blood flow in vivo was also demonstrated. The capability to visualize cellular
features up to the superficial dermis are expected to facilitate evaluation and clinical adoption
of this low-cost diagnostic imaging tool.
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Gong, Cheng; Stratton, Delaney; Curiel-Lewandrowski, Clara; Kang, DongKyun (2020). Speckle-free, near-infrared portable confocal
microscope. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4886643.v1
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AUTHORS (4)
CG
Cheng Gong
DS
Delaney Stratton
CC
Clara Curiel-Lewandrowski
DK
DongKyun Kang