Vectorial birefringence imaging by optical
coherence microscopy for assessing
fibrillar microstructures in the cornea and
limbus
Posted on 2020-01-24 - 21:24
The organization of fibrillar tissue on the micrometer scale carries direct
implications for health and disease but remains difficult to assess in vivo. Polarizationsensitive
optical coherence tomography measures birefringence, which relates to the
microscopic arrangement of fibrillar tissue components. Here, we demonstrate a critical
improvement in leveraging this contrast mechanism by employing the improved spatial
resolution of focus-extended optical coherence microscopy (1.4 μm axially in air and
1.6 μm laterally, over more than 70 μm depth of field). Vectorial birefringence imaging
of sheep cornea ex vivo revealed its lamellar organization into thin sections with distinct
local optic axis orientations, paving the way to resolving similar features in vivo.
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Li, Qingyun; Karnowski, Karol; Untracht, Gavrielle; Noble, Peter; cense, barry; Villiger, Martin; et al. (2020). Vectorial birefringence imaging by optical
coherence microscopy for assessing
fibrillar microstructures in the cornea and
limbus. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4727663.v1
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AUTHORS (7)
QL
Qingyun Li
KK
Karol Karnowski
GU
Gavrielle Untracht
PN
Peter Noble
bc
barry cense
MV
Martin Villiger
DS
David Sampson