Visualizing human photoreceptor and retinal
pigment epithelium cell mosaics in a single
volume scan over an extended field of view
with adaptive optics optical coherence
tomography
Posted on 2020-07-22 - 18:46
Using adaptive optics optical coherence tomography, human photoreceptors and retinal
pigment epithelium (RPE) cells are typically visualized on a small field of view of ~1° to 2°. In addition,
volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we
introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended
imaging area of 4°×4° while maintaining a high (theoretical) transverse resolution (at >7mm pupil
diameter) in the order of 2 µm. A new concept for wavefront sensing is introduced that uses light mainly
originating from the RPE layer and yields images of the RPE cell mosaic in a single volume acquisition.
The capability of the instrument for in vivo imaging is demonstrated by visualizing various cell
structures within the posterior retinal layers over an extended field of view.
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Shirazi, Muhammad Faizan; Brunner, Elisabeth; Laslandes, Marie; Pollreisz, Andreas; Hitzenberger, Christoph; Pircher, Michael (2020). Visualizing human photoreceptor and retinal
pigment epithelium cell mosaics in a single
volume scan over an extended field of view
with adaptive optics optical coherence
tomography. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4910094.v1
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AUTHORS (6)
MS
Muhammad Faizan Shirazi
EB
Elisabeth Brunner
ML
Marie Laslandes
AP
Andreas Pollreisz
CH
Christoph Hitzenberger
MP
Michael Pircher